SwitzerlandSwitzerland

A new prostate cancer blood test

08.02.2011

Zurich – Researchers headed by Wilhelm Krek from ETH Zurich have presented a new strategy for biomarker-based diagnosis of prostate cancer. The researchers said their two-step approach is generally suitable for discovery of serum biomarker signatures corresponding to cancer-causing mutations and subsequent verification (Proc. Natl. Acad Sci USA, doi/10.1073/pnas.1013699108. Comparing wild-type and Pten-null mice’s serum proteins by quantitative proteomics, Krek et al. identified 775 N-linked glycoprotein serum biomarkers. Pten is a prostate cancer biomarker and one of the tumour-suppressors most commonly inactivated in human cancers. From this subproteome, they identified relevant proteins leading to PTEN inactivation in humans. By comparison of the relevant biomarkers with serum proteins occurring in 143 patients with prostate cancer or benign prostatic hyperplasia, they identified 39 ortholog human proteins. Bioinformatic prioritisation of the potential signatures led to a 4-protein diagnostic signature that showed 79% specificity and 85% sensitivity in distinguishing patients with prostate cancer and benign prostatic hyperplasia. The researchers say the signature is suitable for staging of prostate cancer in combination with other diagnostic tests and could prevent current PSA-based over-diagnosis of prostate cancer patients.

SwitzerlandSwitzerland

11.11.2011

Ghent/Geneva - Ablynx rides the biotech rollercoaster. Only days after US-pharma company Pfizer pulled out of a rheumatoid arthritis pact, the Belgian bipharmaceutical outfit expanded its relationship with Merck Serono. Ablynx...

SwitzerlandSwitzerland

10.11.2011

Alschwil - Actelion Ltd. gets a badly needed injection of fresh capital. Under the guidance of the two biggest Swiss banks, UBS and Credit Suisse, the Swiss biopharmaceutical company takes up €171 million agreeing to pay a 4,875%...

SwitzerlandSwitzerland

18.10.2011

Basel/San Diego –Swiss drug company Roche has announced it is buying biotech-company Anadys Pharmaceuticals for US$230 million. Under the terms of the merger agreement, Roche will commence an all cash tender offer for all...

Germany, SwitzerlandSwitzerland

12.10.2011

The Swiss technology transfer organisation Unitectra is the winner of the European Biotechnica Award 2011. The specialist for technology transfer received the award from hands of Lower Saxony's Minister for Economy Jörg Bode. The...

SwitzerlandSwitzerland

01.10.2011

Liestal – Swiss Santhera AG has announced strict savings measures. Out of a total of 21 employees, almost every second is now slated to be sacked. The biotech firm is closing its department of preclinical development and scaling...

SwitzerlandSwitzerland

01.10.2011

Schlieren – Swiss biotechnology company Cytos AG has finally devised a plan to help its lead candidate into Phase II, but to achieve it, the cash-strapped company is having to slash its workforce by a whopping 85%. To ensure the...

SwitzerlandSwitzerland

01.10.2011

Geneva – Swiss biotech Addex Pharmaceuticals AG has regained all rights to its metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM) programme from Merck&Co, (known as MSD outside the United States and...

SwitzerlandSwitzerland

01.10.2011

Hamburg – When the compound EVT302 failed proof-of-concept testing in the spring of 2009, investors began backing away from Evotec AG shares. Now the selective MAO-B inhibitor is back, and has powered a leap in the company’s...

SwitzerlandSwitzerland

15.09.2011

Zurich – The FDA has posted a manufacturing warning to Lonza following an inspection of the firm's microbial production site for Eisai’s cancer drug Ontak in Hopkinton. However, analysts at Vontobel said that the impact of the...

SwitzerlandSwitzerland

30.08.2011

Schlieren - Swiss biotechnology company Cytos has devised a plan to get its lead candidate into Phase II. To achieve this, the cash strapped company will slash its workforce, as previously announced, by 85%. To ensure the...

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