SwedenSweden

Backing for PIGF-blocker

14.08.2008

Lund/Leuven/Basel – Swedish drug development company BioInvent International AB and drug development partner Belgian ThromboGenics NV have entered into a multimillion-euro licensing agreement with Swiss pharma giant Roche. The strategic alliance encompasses the jointly developed anti-cancer agent TB-403, a humanised monoclonal antibody that blocks Placental Growth Factor (PIGF), one of the growth factors responsible for the development of new blood vessels. TB-403 (Anti-PIGF) has completed its Phase I clinical trial, and recently received approval to enter a Phase Ib dose-escalation trial. TB-403 was in-licensed by ThromboGenics from the Flanders Institute for Biotechnology (VIB) at the University of Leuven (Belgium), where the therapeutic potential of anti-PlGF agents to treat cancer was first developed.
The companies announced in June that BioInvent and ThromboGenics will receive EUR50m in an upfront payment from Roche. In addition, the Swedish and Belgian firms could potentially receive up to a450m over the term of the collaboration. Payments are dependent on the successful completion of a series of development and commercial milestones for multiple indications, as well as royalties on potential product sales, including any backup antibodies based on the inhibition of PIGF. ThromboGenics will receive 60% of the revenue from the deal, while BioInvent will take home 40%. Both firms retain the promotion rights for the antibody in the Nordic, Baltic and Bene-

lux regions. Roche receives a worldwide exclusive license to develop and commercialise the product, and assumes responsibility for all future development costs.

Roche will also provide the two companies with funding for research on non-cancer indications.

SwedenSweden

12.03.2012

Gothenburg – Researchers at the Sahlgrenska Academy have discovered a previously unknown mechanism which helps intestinal bacteria to affect the formation of blood vessels. In a study of mice, the team led by Fredrik Bäckhed...

SwedenSweden

08.03.2012

Swiss Nestlé S.A. has extended its collaboration agreement with BioGaia AB. The world’s largest nutrition company is paying up to €50.8m for a perpetual licence to use BioGaia’s patented Lacto­bacillus reuteri in infant nutrition...

SwedenSweden

08.03.2012

Stockholm – Swedish drug delivery specialist Orexo AB has announced the intention to cut its headcount by 30% in order to reduce the company's burn rate. The personnel reduction by 35 people is expected to lower the costs by a...

SwedenSweden

07.03.2012

After a long period of negotiations, Sweden’s Orexo AB and Belgium’s Janssen Pharmaceutica have terminated their joint research programmes. “Unfortunately, we lack the funds to continue on our own to develop the OX-CLI and OX-ESI...

SwedenSweden

06.03.2012

Uppsala/Moscow – Vaccine adjuvant specialist Isconova AB is set to begin receiving royalties and product revenues from Russian partner VetBioChem. The veterinary medicine company has launched two new rabies vaccines for dogs and...

SwedenSweden

23.02.2012

Stockholm - Probiotics can help prevent diseases, Swedish researchers have found out. The results are in sharp contrast with all health claim judgements involving probiotics published by the EU's food watchdog EFSA up to now. The...

SwedenSweden

16.02.2012

Huddinge – Full stop for one of Sweden's most promising biotech companies. Karo Bio has terminated the trial of its late-stage cholesterol drug eprotirome and won't proceed with its plans to spin off its preclinical operations....

SwedenSweden

19.12.2011

Helsingborg/Exton – Swedish drug developer DuoCort Pharma AB has been purchased by US-based biopharmaceuticals maker ViroPharma Inc. ViroPharma paid around €25m up front, but DuoCort’s former owners could end up receiving €97m...

SwedenSweden

15.12.2011

Stockholm/Cologne – Researchers at the Swedish Karolinska Institute and the University of Cologne have identified a new protein-based defense mechanism against cancer (Struct. & Molec. Biology, doi: 10.1038/10.1038/nsmb.2188)....

SwedenSweden

15.12.2011

Craigavon/Uppsala – Irish Almac Discovery, a member of the Almac Group, will begin cooperating with Uppsala-based Beactica AB to develop new cancer drug candidates. In late November, the companies announced that Beactica’s Sprint...

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