PortugalPortugal

Determining factors in stem cell fate

14.09.2009

Coimbra/San Francisco/Munster – Portuguese and US researchers have discovered a new factor that determines whether an embryonic stem cell (ESC) will remain pluripotent or not. After the team under Miguel and Joao Ramalho-Santos (Universities of California and Coimbra) knocked down the expression of the cdk1 gene, which activates gene expression by opening up the chromatin, mouse ESCs lost their ability to develop into any type of cells (Nature, doi 10.1038/nature08212). The researchers speculate that unpacking the DNA is involved in pluripotency, as well as in somatic cell reprogramming to the pluripotent state. Another research group from Germany has demonstrated that reprogramming human neural progenitor cells to a pluripotent state could be managed by expression of only one gene – the oct4 gene (Nature, doi: 10.1038/nature08436). Their findings open up the way to screen drugs with reprogrammed human cells once a stable cell line has been established. Clinical application of stem cells still has a long way to go. An initial clinical trial set up by Geron Corp. was recently halted by the US FDA for safety reasons before it even began.

PortugalPortugal

19.08.2008

Lisbon – The international contract research organisation Chiltern sees potential for growth in Portugal. In May, it opened a new office in Lisbon that will be managed by Ricardo Diaz. Over the last two years, numbers of clinical...

PortugalPortugal

19.03.2008

Porto – 164 farmers planted a total of 4,199 hectares of genetically modified maize in Portugal in 2007, according to a report issued by the Portuguese Ministry of Agriculture. That represents a 330% increase compared to 2006,...

PortugalPortugal

22.11.2007

Cantanhede – Biogen Idec (Cambridge, US) and the Portuguese biopark Biocant in the Coimbra region have signed a socalled ‘Sponsored Research Agreement’ worth an undisclosed amount. Under the terms of the agreement, researchers...

Portugal, SpainPortugal

11.07.2007

Oeiras/Navarra – Portuguese antibody and genomics specialist Biotecnol SA and the Spanish university spin-off Digna Biotech will develop a process for manufacturing cardiotrophin-1 (CT-1) for the treatment of ischemic-reperfusion...

PortugalPortugal

11.07.2007

Porto – In September 2005, the Portuguese government established a decree law (No. 160/2005) on the co-existence between genetically modified organisms (GMO), conventional and organic crops. In short, it recommends a minimum...

PortugalPortugal

11.07.2007

Almada – transADVANcis Lda, a consultancy firm for nanotechnology and life sciences executives, has launched a website called www.nanogolive.com. With the new portal, on which anyone from the nanotechnology and life science...

PortugalPortugal

16.05.2007

Porto – Two Portuguese biotech companies have won the national idea contest for bio-entrepreneurs (Concurso de Ideias Bioempreendedor 2006), organized every year by the Portuguese Association of Bioindustries (APBio) and the...

PortugalPortugal

16.03.2007

Port Salvo – Biotrend S.A., developers of high-value compounds based in Lisbon, has closed a second investment round with the public venture capital outfit PME Investimientos, ending with a total investment exceeding 1 million...

PortugalPortugal

16.03.2007

Porto Salvo – Alfama, developers of small molecule drugs, has opened a laboratory in Boston, Massachusetts, in order to achieve US presence. The company will carry out research on the effects of self-developed molecules on...

Italy, PortugalPortugal

16.09.2006

Milan/Sintra – The Italian pharmaceutical company Recordati S.p.A agreed in July to acquire Jaba Farmacêutica (Sintra, Portugal) and all other pharmaceutical businesses belonging to the Grupo Jaba in Portugal. The purchase price...

Displaying results 11 to 20 out of 37

< Previous 11-20 Next >

© 2007-2014 BIOCOM

http://www.european-biotechnology-news.com/nc/news/messages-archive/archive-portugal/browse/1/article/determining-factors-in-stem-cell-fate.html

Product of the week

Products

Events

All Events

Current issue

All issues