NorwayNorway

Clavis partner in companion diagnostics partnership

23.04.2010

Oslo – Norwegian cancer specialist Clavis Pharma ASA announced yesterday that its US-based development partner Clovis Oncology for CP-4126 has signed an agreement with Ventana Medical Systems, Inc. to develop a companion diagnostic to the novel formulation of gemcitabine. The companion diagnostic is being developed to identify pancreatic cancer patients with low-level tumour expression of the human equilibrative nucleoside transporter 1 (hENT1) protein. Ultimately, the use of a hENT1 companion diagnostic will enable oncologists to identify responders to the treatment. The hENT1 transporter on tumour cells plays a crucial role in the uptake of cytotoxic nucleoside-based drugs and their low level or absence has been correlated with a poor clinical response to treatment with drugs such as gemcitabine and cytarabine. It is estimated that pancreatic tumours in up to two-thirds of patients have low levels of hENT1 on the tumour cell surface. CP-4126, and other drug candidates in Clavis Pharma's portfolio, have been developed using its Lipid Vector Technology (LVT), which enables the compound to enter cancer cells independently of hENT1. CP-4126 is an LVT form of gemcitabine, the current standard treatment for advanced pancreatic cancer, and which is also used in combination with other chemotherapy agents for the treatment of other cancers, including ovarian, non-small cell lung, and breast cancer.

NorwayNorway

05.04.2011

Oslo – Norwegian Algeta ASA has entered a research collaboration with Genzyme to evaluate the potential of its Thorium platform Under the terms of the agreement, Genzyme will provide access to a novel tumour-targeting antibody,...

NorwayNorway

05.04.2011

Trondheim – Norway-based APIM Therapeutics AS has received a follow-up investment from Sarsia Seed, one of its previous investors. APIM focusses on novel drug candidates that potentiate the action of current chemo­therapeutics to...

NorwayNorway

04.11.2010

Oslo – Norwegian diagnostic specialist DiaGenic ASA has raised NOK70m (EUR 8.5m) through the sale of 140 million shares at NOK0.50 per share in a private placement to new and existing investors. DnB NOR Markets acted as manager...

NorwayNorway

03.11.2010

Oslo – The Oslo Cancer Cluster and the Shanghai Institute of Materia Medica (SIMM), have signed a memorandum of understanding aimed at accelerating the development and adoption of new cancer therapies. Overall, the collaboration...

NorwayNorway

18.09.2010

Oslo/Berlin – Algeta is cashing in on its lead product Alpharadin, a targeted alpha-radiopharmaceutical in clinical trials for treating bone metastases in cancer patients. Bayer Schering Pharma has agreed to pay the Norwegian...

NorwayNorway

11.07.2010

Lysaker – Norwegian biopharmaceutical company PCI Biotech Holding ASA has strengthened the company’s equity by a11m (NOK90m) through a share issue of 2.25 million shares with preemptive subscription rights for existing...

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