ItalyItaly

Newron and Merck Serono’s Safinamide misses goal in pivotal Parkinson's phase III study

05.11.2010

Milan/Geneva – Italian drugmaker Newron Pharmaceuticals and its partner Merck Serono have failed to demonstrate that its investigational drug Safinamide provides a significant benefit as a treatment for advanced Parkinson’s disease as an add-on therapy to levodopa. In a three-arm phase III extension study, neither a 50 mg nor a 100 m mg once daily dose of the drug achieved the primary efficacy study endpoint of improving dyskinesia after 24 months of treatment. However, safety was confirmed in the study involving 544 patients. Dyskinesia, which consists of involuntary and twisting movements of the face and body, is a major complication of levodopa therapy, resulting in a significant deterioration of patient quality of life. At baseline, 32% of patients showed troublesome dyskinesia. The companies’ goal is to file a MAA for their alpha-aminoamide MAO-B blocker as an add-on therapy for dopamine agonist therapy in patients with early Parkinson's disease, and as an add-on for levodopa therapy in patients with advanced Parkinson's.

ItalyItaly

04.11.2010

Rome/Milan – Together with two Italian research institutes, British drug giant Glaxo­SmithKline has begun to develop a therapy for the heriditary immune defect ADA-SCID, which affects only 350 children worldwide. Fondazione...

ItalyItaly

03.11.2010

Rome – When it comes to GMOs, the gap between Italy’s federal government and its regions that has marked the country for years is rapidly widening into a gulf. The latest rupture was on display at the October session of the...

ItalyItaly

18.09.2010

Valletta – A new Life Sciences Park is to be created on the outskirts of Malta’s capital Valletta. The EUR20m project will provide space for companies operating in biotechnology and medical sciences. The park will be located in...

ItalyItaly

17.09.2010

Verona – Scientists at Glaxo­SmithKline in Verona have discovered that specific neurons in the amygdala control how mice react to fear stimuli. When they switched off the so-called Type I cells in the animals’ amyg­dala, the mice...

ItalyItaly

29.08.2010

San Michele all’Adige – The genetic code of the Golden Delicious apple has been deciphered. Led by Riccardo Velasco at the Edmund Mach Foundation in San Michele all’Adige in Italy’s Trentino province, a team of scientists from 20...

ItalyItaly

12.07.2010

: It’s hard to be a pro-GMO campaigner in Italy. Since 2001, the regions there have not implemented the plans for coexistence that were suggested by a ministerial decree. Instead, there was a de facto Italian moratorium on GM...

ItalyItaly

10.07.2010

Milan – One of Italy’s biggest biotech players wants to raise EUR58m to boost its pipeline of cancer therapies. The round will be closed on July 16th. With operating costs of EUR22.5m and a total loss of about EUR17m in 2009,...

ItalyItaly

10.07.2010

Milan – Italian researchers have restored sight to blind patients using stem cells from the patients’ own bodies. In a study published by the New England Journal of Medicine (10.1056/NEJMoa0905955), scientists from Modena and...

ItalyItaly

13.05.2010

Rome/Maryland – The Vatican has taken a bold step into unchartered territory with its decision to finance new research into the potential use of adult stem cells for the treatment of intestinal disease and possibly other...

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No liability assumed, Date: 22.10.2014


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