ItalyItaly

Researchers decipher key molecule for onset of addiction

29.11.2010

Modena/London – Researchers from Germany, Italy and the UK have
identified a molecule that is key to the onset of addiction and also
involved into memory formation (EMBO Journal, doi:10.1038/emboj.2010.279). According to results of the team headed by Pierluigi Nicotera, expression of the type 2 ryanodine receptor (RyR2) leads to sustained increase of calcium in nerve cells, the signal responsible for rearrangement of brain connections. When the researchers blocked the Ca2+ release channel present on the endoplasmic reticulum in a mouse model for onset of drug dependence, sensitization to nicotine-induced habituated locomotion was abolished. The researchers conclude that gene-dependent reprogramming of Ca2+ signalling is involved in nicotine- or cocaine induced behavioural changes. RyR2 upregulation was itself required for long-term phosphorylation of CREB in a positive-feedback signalling loop.

ItalyItaly

12.06.2011

Milan – Everyone agrees that Italy is not Greece, but it is common wisdom that the country could also be doing better. Considering the meagre growth of the Italian economy in the last decade however, data fom the 2011 survey of...

ItalyItaly

01.04.2011

Milan – Italian drugmaker Newron Pharmaceuticals S.p.A. and Merck Serono have broadened the scope of their 5-year-old collaboration on CNS drugs. In addition to the Parkinson’s treatment safinamide, under the terms of a new...

ItalyItaly

16.02.2011

Milan/Berlin – Swiss-Italian biotech Philogen SpA has revoked its plan to sell a 23% stake worth EUR65.3m and go public on the Milan stock exchange this Friday. The move came after German Bayer HealthCare unexpectedly terminated...

ItalyItaly

06.02.2011

Rome – The EUR2.5m ERC Advanced Grants are the Grammies of European science – not in the same league as a Nobel Prize, but still a lucrative honor. In the fourth round since 2007, the European Research Council awarded some a590m...

ItalyItaly

09.11.2010

Genoa/Philadelphia — The inexpensive anti-gout drug allopurinol can counteract colorectal adenoma progression, according to data presented yesterday at the 9th Annual AACR Frontiers in Cancer Prevention Research Conference...

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No liability assumed, Date: 29.09.2014


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