ItalyItaly

Newron and Merck Serono’s Safinamide misses goal in pivotal Parkinson's phase III study

05.11.2010

Milan/Geneva – Italian drugmaker Newron Pharmaceuticals and its partner Merck Serono have failed to demonstrate that its investigational drug Safinamide provides a significant benefit as a treatment for advanced Parkinson’s disease as an add-on therapy to levodopa. In a three-arm phase III extension study, neither a 50 mg nor a 100 m mg once daily dose of the drug achieved the primary efficacy study endpoint of improving dyskinesia after 24 months of treatment. However, safety was confirmed in the study involving 544 patients. Dyskinesia, which consists of involuntary and twisting movements of the face and body, is a major complication of levodopa therapy, resulting in a significant deterioration of patient quality of life. At baseline, 32% of patients showed troublesome dyskinesia. The companies’ goal is to file a MAA for their alpha-aminoamide MAO-B blocker as an add-on therapy for dopamine agonist therapy in patients with early Parkinson's disease, and as an add-on for levodopa therapy in patients with advanced Parkinson's.

ItalyItaly

12.06.2011

Milan – Everyone agrees that Italy is not Greece, but it is common wisdom that the country could also be doing better. Considering the meagre growth of the Italian economy in the last decade however, data fom the 2011 survey of...

ItalyItaly

01.04.2011

Milan – Italian drugmaker Newron Pharmaceuticals S.p.A. and Merck Serono have broadened the scope of their 5-year-old collaboration on CNS drugs. In addition to the Parkinson’s treatment safinamide, under the terms of a new...

ItalyItaly

16.02.2011

Milan/Berlin – Swiss-Italian biotech Philogen SpA has revoked its plan to sell a 23% stake worth EUR65.3m and go public on the Milan stock exchange this Friday. The move came after German Bayer HealthCare unexpectedly terminated...

ItalyItaly

06.02.2011

Rome – The EUR2.5m ERC Advanced Grants are the Grammies of European science – not in the same league as a Nobel Prize, but still a lucrative honor. In the fourth round since 2007, the European Research Council awarded some a590m...

ItalyItaly

29.11.2010

Modena/London – Researchers from Germany, Italy and the UK have identified a molecule that is key to the onset of addiction and also involved into memory formation (EMBO Journal, doi:10.1038/emboj.2010.279). According to results...

ItalyItaly

09.11.2010

Genoa/Philadelphia — The inexpensive anti-gout drug allopurinol can counteract colorectal adenoma progression, according to data presented yesterday at the 9th Annual AACR Frontiers in Cancer Prevention Research Conference...

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