ItalyItaly

Genetic profile enables personalised choice of blood pressure drug

24.11.2010

Milan – Researchers headed by Dr. Chiara Lanzani at the Italian drugs manufacturer Sigma Tau have identified a gene signature that enables more targeted decisions in the choice of blood pressure-lowering drugs (Science Translational Medicine, 24 November). The researchers have discerned a genetic pattern that identifies 25% of responders to the sodium pump blocker Rostafuroxin. In a phase II trial, Lanzani and colleagues found that specific gene variants of the adducin gene family and of genes associated with high levels of the hormone ouabain led to rostafuroxin-inhibited pump activation and hypertension. The results open up the possibility of improved patient stratification, as they allow predictions to be made about the effectiveness of rostafuroxin (but not that of any other antihypertensive drugs) in patients carrying key gene variants. Because the mechanisms blocked by rostafuroxin also underlie high blood pressure-related organ damage, this drug may also reduce the risk of heart attack or other cardiovascular problems in patients beyond that typically expected from reduced blood pressure alone.

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12.06.2011

Milan – Everyone agrees that Italy is not Greece, but it is common wisdom that the country could also be doing better. Considering the meagre growth of the Italian economy in the last decade however, data fom the 2011 survey of...

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01.04.2011

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16.02.2011

Milan/Berlin – Swiss-Italian biotech Philogen SpA has revoked its plan to sell a 23% stake worth EUR65.3m and go public on the Milan stock exchange this Friday. The move came after German Bayer HealthCare unexpectedly terminated...

ItalyItaly

06.02.2011

Rome – The EUR2.5m ERC Advanced Grants are the Grammies of European science – not in the same league as a Nobel Prize, but still a lucrative honor. In the fourth round since 2007, the European Research Council awarded some a590m...

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29.11.2010

Modena/London – Researchers from Germany, Italy and the UK have identified a molecule that is key to the onset of addiction and also involved into memory formation (EMBO Journal, doi:10.1038/emboj.2010.279). According to results...

ItalyItaly

09.11.2010

Genoa/Philadelphia — The inexpensive anti-gout drug allopurinol can counteract colorectal adenoma progression, according to data presented yesterday at the 9th Annual AACR Frontiers in Cancer Prevention Research Conference...

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