Austria, Germany, ItalyItaly

Cows Produce Therapeutics

08.05.2004

Vienna/Munich/Bari - Researchers from Austria, Germany and Italy have cloned nine cows to produce a special anti-cancer antibody in their blood (Proc. Natl. Acad. Sci., April 22, doi 10.1073). With the “cow system” they yielded up to 0.1g/L of the bi-specific single chain antibody. In an in vitro assay the antibody lead to death of more than 90% of melanoma cells by activating human T-killer lymphocytes: With its first specifity the antibody binds specifically to the proteoglycan of the mela-noma cells. The other binding site activates killer cells through binding of their CD 28 surface receptor.
The expression of therapeutic antibodies in animal blood cells could be a promising route to overcome limitations of other expression systems for therapeutic proteins, according to the researchers around Gottfried Brem from University of Veterinary Medicine in Vienna. The new gene farming approach offers higher yields and proteins with higher stability in the human body.

ItalyItaly

12.06.2011

Milan – Everyone agrees that Italy is not Greece, but it is common wisdom that the country could also be doing better. Considering the meagre growth of the Italian economy in the last decade however, data fom the 2011 survey of...

ItalyItaly

01.04.2011

Milan – Italian drugmaker Newron Pharmaceuticals S.p.A. and Merck Serono have broadened the scope of their 5-year-old collaboration on CNS drugs. In addition to the Parkinson’s treatment safinamide, under the terms of a new...

ItalyItaly

16.02.2011

Milan/Berlin – Swiss-Italian biotech Philogen SpA has revoked its plan to sell a 23% stake worth EUR65.3m and go public on the Milan stock exchange this Friday. The move came after German Bayer HealthCare unexpectedly terminated...

ItalyItaly

06.02.2011

Rome – The EUR2.5m ERC Advanced Grants are the Grammies of European science – not in the same league as a Nobel Prize, but still a lucrative honor. In the fourth round since 2007, the European Research Council awarded some a590m...

ItalyItaly

29.11.2010

Modena/London – Researchers from Germany, Italy and the UK have identified a molecule that is key to the onset of addiction and also involved into memory formation (EMBO Journal, doi:10.1038/emboj.2010.279). According to results...

ItalyItaly

09.11.2010

Genoa/Philadelphia — The inexpensive anti-gout drug allopurinol can counteract colorectal adenoma progression, according to data presented yesterday at the 9th Annual AACR Frontiers in Cancer Prevention Research Conference...

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