GermanyGermany

Non-invasive toxicity testing

04.11.2010

Mannheim – German researchers have patented a non-invasive sensor chip that can permanently monitor kidney and liver function. “Our chip can be used for toxicity testing of preclinical drugs in animals. Next year, we are going to apply for the CE mark to use it in human diagnostics,” Prof. Norbert Gretz from Mann­heim University told EuroBiotechNews. Through the skin, the sensor measures how fast flourescence-labelled, organ-specific markers are eliminated from the bloodstream. An LED excites the labelled markers in the blood and tracks their fluorescence in real-time with a photodiode.
“We have already miniaturised our chip, which continously sends all its data to a PC,” says Gretz. Currently, chip size is only 3 x 3 x 2 mm, but the researchers want to shrink it even further for use on mice in preclinical drug candidate testing. Gretz is planning to commercialise the technique soon, saying he plans to begin with services to the bio­pharmaceutical industry. Because both the liver and fluorescence marker have already been approved for diagnostic purposes, only the device has to apply for the CE mark.
Gretz has also shown that his invention works for kidney function testing. Within the EU’s ‘Place-it’ project, he provided the proof-of-concept. In the EU project, elimination speed of fluorescein-labeled inulin was used to monitor the kidney function of rats (publication submitted), but Gretz will be using “a biomarker that gives a stronger signal” for developing the diagnostic test.
According to the researcher, the best way to commercialise his device would be to develop a prototype, optimise it with a partner and then market it with in cooperation with a strong sales organisation.

GermanyGermany

27.10.2011

Leverkusen - Bayer Pharma has a lucky streak. The pharma division of the German chemical giant announced positive Phase III results from regorafenib in colorectal cancer. “We are extremely encouraged by the result of this...

GermanyGermany

24.10.2011

Leverkusen - A short statement from the European Medicines Agency (EMA) and a big step for the German biotech Biofrontera. The agency issued a favourable opinion on Biofrontera's marketing approval application for its drug for...

GermanyGermany

14.10.2011

Leverkusen/San Francisco - Bayer HealthCare and Onyx Pharmaceuticals will not to court over Nevaxar. The two companies reached an agreement related to regorafenib, a late-stage oncology compound. Regorafenib is an oral...

GermanyGermany

11.10.2011

Ingelheim/Ridgefield –Boehringer Ingelheim’s COPD treatment Combivent Respimat has been approved by the U.S. Food and Drug Administration (FDA) for the US market. The new, propellant-free inhaler product for the beta adrenergic...

GermanyGermany

01.10.2011

Rostock – German researchers say overexpression of one of the 49 transport proteins that shuttle substances over the blood-brain barrier could be the key to treating Alzheimer’s disease. In mice, the group headed by Jens Pahnke...

GermanyGermany

27.09.2011

Rehovot/Monheim – Bayer Crop Science may be a step closer to introducing desirable traits in wheat. In the collaboration with Israeli Evogene Ltd. the German company has reached a milestone. Utilising Evogene‘s proprietary...

GermanyGermany

22.09.2011

Willich – Brasilian biopolymer producer Braskem and German bioplastics compounding specialist FKuR GmbH, have signed a compounding agreement for green polyethylene. The tailor-made product will be a first in Europe, according...

GermanyGermany

08.09.2011

Leverkusen - It was a black Tuesday for Bayer. After rumours were leaked out that the FDA has doubts over the German pharmaceutical company's potential blockbuster Xarelto, the shares temporarily dropped as much as 17 percent....

GermanyGermany

06.09.2011

Bad Homburg - German VC firm Creathor venture announced the first closing of its Creathor Venture Fund III. Now, the company is poised to mete out €51million of fresh capital to start-ups. Life science companies will be among the...

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