GermanyGermany

Stopping malaria at the membrane

08.07.2010

Hamburg – To survive in man, the malaria parasite Plasmodium falciparum needs to enter the red blood cells for reproduction. Researchers from the Bernhard ­Nocht Institute for Tropical Medicine in Hamburg have now identified the internal signal that triggers the invasion of human erythrocytes. “To enter the cell, the parasites first have to come into intimate contact with the blood cells,” says Tim Gillberger, who conducted the research (PLoS Pathog. 6(6):e1000941). “If we are able to block the molecular mechanism behind that process, the pathogen wouldn’t stand a chance of successful infection.“ Gillberger and colleagues have already started compound screening for so-called PfPKA inhibitors – compounds that block the enzyme cAMP dependent protein kinase A. As the researchers reported in mid-June, PfPKAs are required for the formation of so-called tight junctions between Plasmodium and the blood cell. The enzymes activate the parasite surface protein AMA1 by phosphorylation, which triggers formation of tight junction formation and thus blood cell invasion. Gilberger believes the discovery opens the path to the development of new malaria drugs and vaccines.



Germany, FranceGermany

21.12.2011

Martinsried/Paris - Sanofi has done some Christmas shopping in Munich and has licensed Scil Technology’s programme for the regenerative treatment of osteoarthritis and cartilage disorders. Under the agreement, Scil could reap up...

GermanyGermany

20.12.2011

Monheim - It's nearly Christmas, and Bayer Crop Science gives out some presents. As the company announced, a $750 million settlement with U.S. rice farmers is now binding and can move forward. In summer the German firm had agreed...

GermanyGermany

16.12.2011

Bonn – Germany’s federal government is prolonging one of its most successful measures to date for stimulating the establishment of high-tech companies – the High-Tech-Gründerfonds (HTGF). The HTGF was launched in 2005 with €272m...

GermanyGermany

15.12.2011

Leverkusen – One short statement from the European Medicines Agency (EMA) means one giant step for German biotech company Biofrontera. The agency issued a favourable opinion on the firm’s marketing approval application for its...

GermanyGermany

15.12.2011

While the European sovereign debt crisis keeps capital markets in a choke-hold, with potential negative effects on the financing situation in many industries – including biotech – there was encouraging news for drug-developing...

GermanyGermany

08.12.2011

Heidelberg – There is still life in the European life science finance. EMBL Ventures has closed a €40m fund. The early stage investor and the venture capital arm of the European Molecular Biology Laboratory(EMBL) announced the...

GermanyGermany

03.11.2011

Düsseldorf – BIO-Europe 2011 in Düsseldorf has again broken all previous records in terms of participants and company numbers. More than 3,000 representatives from 1,800 companies registered for Europe‘s largest partnering event....

GermanyGermany

02.11.2011

Brussels/San Francisco – As the biggest biotech partnering event on the continent, BioEurope, draws to a close, the venture capital community sent ambivalent messages for life sciences. Dow Jones VentureSource, an analyst,...

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