GermanyGermany

Researchers crack DNA reprogramming mechanism

01.04.2011

Saarbruecken – For a decade, stem cell researchers have tried to unravel how epi­gentic reprogramming works at the molecular level. Now, German researchers have discovered how the epigenetic code in the paternal part of the genome of a zygote is reset, and how the maternal genome conserves epigenetic marks on its DNA. A team under Jörn Walter from the University of Saarbrücken found that 5’ methyl cytosine marks on the paternal genome, which block transcription, disappeared in male pro­nuclei of the zygote, while a new modification termed 5’ hydroxymethl cytosine occurred. The transformation is catalysed by the tet3 enzyme in the paternal pronucleus, and erasure of the epigenetic memory is prevented in the maternal genome by another enzyme called PGC7. The discovery of the enzymes responsible for resetting a genome is good news for stem cell researchers who try to coax stem cells to differentiate into particular cells in the human body. It opens up targeted activation of genes that drive development in selected cell lines.

Germany, FranceGermany

21.12.2011

Martinsried/Paris - Sanofi has done some Christmas shopping in Munich and has licensed Scil Technology’s programme for the regenerative treatment of osteoarthritis and cartilage disorders. Under the agreement, Scil could reap up...

GermanyGermany

20.12.2011

Monheim - It's nearly Christmas, and Bayer Crop Science gives out some presents. As the company announced, a $750 million settlement with U.S. rice farmers is now binding and can move forward. In summer the German firm had agreed...

GermanyGermany

16.12.2011

Bonn – Germany’s federal government is prolonging one of its most successful measures to date for stimulating the establishment of high-tech companies – the High-Tech-Gründerfonds (HTGF). The HTGF was launched in 2005 with €272m...

GermanyGermany

15.12.2011

Leverkusen – One short statement from the European Medicines Agency (EMA) means one giant step for German biotech company Biofrontera. The agency issued a favourable opinion on the firm’s marketing approval application for its...

GermanyGermany

15.12.2011

While the European sovereign debt crisis keeps capital markets in a choke-hold, with potential negative effects on the financing situation in many industries – including biotech – there was encouraging news for drug-developing...

GermanyGermany

08.12.2011

Heidelberg – There is still life in the European life science finance. EMBL Ventures has closed a €40m fund. The early stage investor and the venture capital arm of the European Molecular Biology Laboratory(EMBL) announced the...

GermanyGermany

03.11.2011

Düsseldorf – BIO-Europe 2011 in Düsseldorf has again broken all previous records in terms of participants and company numbers. More than 3,000 representatives from 1,800 companies registered for Europe‘s largest partnering event....

GermanyGermany

02.11.2011

Brussels/San Francisco – As the biggest biotech partnering event on the continent, BioEurope, draws to a close, the venture capital community sent ambivalent messages for life sciences. Dow Jones VentureSource, an analyst,...

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