GermanyGermany

New method identifies proteins that trigger anti-tumour responses

11.05.2010

Heidelberg – Individualised cancer immunotherapy holds great promise, but clinical results have been disappointing because the tumour antigens used to date have not been able to induce sufficiently strong immune responses. Now, German researchers at the University of Heidelberg have presented a novel automated method that is capable of comprehensively identifying candidate tumour proteins that spontaneously trigger strong immune responses (JCI, doi: 10.1172/JCI37646). The team headed by Christel Herold-Mende applied two-dimensional chromatography to fractionate the tumour proteome, and subsequently verified that these protein fractions activate tumour-specific memory immune cells. Applying this method to human cell lysates, the authors identified two previously unknown tumour proteins (transthyretin and calgranulin B/S100A9) that were targeted by the immune system in a patient with a malignant brain tumour. Herold-Mende et al. found that the immune system in 4 out of 10 other brain tumour patients also targeted these proteins. The method is reproducible, fast and inexpensive, and the authors hope that it will be suitable for identifying candidate tumour proteins for the development of individualised cancer immunotherapies.

Germany, FranceGermany

21.12.2011

Martinsried/Paris - Sanofi has done some Christmas shopping in Munich and has licensed Scil Technology’s programme for the regenerative treatment of osteoarthritis and cartilage disorders. Under the agreement, Scil could reap up...

GermanyGermany

20.12.2011

Monheim - It's nearly Christmas, and Bayer Crop Science gives out some presents. As the company announced, a $750 million settlement with U.S. rice farmers is now binding and can move forward. In summer the German firm had agreed...

GermanyGermany

16.12.2011

Bonn – Germany’s federal government is prolonging one of its most successful measures to date for stimulating the establishment of high-tech companies – the High-Tech-Gründerfonds (HTGF). The HTGF was launched in 2005 with €272m...

GermanyGermany

15.12.2011

Leverkusen – One short statement from the European Medicines Agency (EMA) means one giant step for German biotech company Biofrontera. The agency issued a favourable opinion on the firm’s marketing approval application for its...

GermanyGermany

15.12.2011

While the European sovereign debt crisis keeps capital markets in a choke-hold, with potential negative effects on the financing situation in many industries – including biotech – there was encouraging news for drug-developing...

GermanyGermany

08.12.2011

Heidelberg – There is still life in the European life science finance. EMBL Ventures has closed a €40m fund. The early stage investor and the venture capital arm of the European Molecular Biology Laboratory(EMBL) announced the...

GermanyGermany

03.11.2011

Düsseldorf – BIO-Europe 2011 in Düsseldorf has again broken all previous records in terms of participants and company numbers. More than 3,000 representatives from 1,800 companies registered for Europe‘s largest partnering event....

GermanyGermany

02.11.2011

Brussels/San Francisco – As the biggest biotech partnering event on the continent, BioEurope, draws to a close, the venture capital community sent ambivalent messages for life sciences. Dow Jones VentureSource, an analyst,...

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