Diabetes: miRNA triggers insulin resistance
Cologne – Insulin resistance represents a key process in the development of diabetes II, which has reached epidemic proportions in industrial nations. Researchers from TaconicArtemis Pharmaceuticals and from the University of Cologne have identified an miRNA and its target protein as important mediators of insulin resistance in vivo. In obese mice, over-expression of the regulatory miR143 in the liver impaired insulin-stimulated AKT activation and glucose homeostatis. In contrast, mice deficient for mi143 were protected from developing obesity-associated insulin resistance. The researchers identified ORP8 as mi143 target protein. In cultured liver cells, reduced ORP8 expression impaired the ability of insulin to induce AKT activation. The researchers believe the miR143-ORP8 pathway is a promising potential target for drug development.