GermanyGermany

Aptamers from L-oligonucleotides proven safe and non-toxic

04.05.2010

Berlin - On Monday, German NOXXON Pharma AG announced the successful completion of a Phase I trial with the 1st "Spiegelmer" NOX-A12, an antagonist of stromal cell-derived factor-1 (SDF-1). Final data analysis demonstrated an excellent safety and tolerability up to the highest tested dose of 10.8 mg/kg. In addition, analysis by flow cytometry revealed a long-lasting and dose dependent mobilization of WBC and CD34 positive cells. The protocol also allowed that an additional group of volunteers received leukapheresis, should certain thresholds of circulating CD34 positive cells were reached, to further characterize the mobilized cells and this was undertaken. Noxxon intends to develop its intravenously administered drug candidate in haematological malignancies and/or solid tumours. NOX-A12 is scheduled to enter a multiple dose Phase I clinical trial by mid 2010, and phase II clinical testing soon thereafter. NOX-A12 has been evaluated in models of stem cell mobilization, angiogenesis, inflammation and lung and kidney injury. In all of these models, NOX-A12 reduced pathological angiogenesis and tissue remodelling. In preclinical safety and two weeks toxicology studies, NOX-A12 was established as safe with no organ toxicity. In particular, NOX-A12 did not exert any immunotoxicity effects, such as Toll-like receptor activation or changes in cytokine levels.

Germany, FranceGermany

21.12.2011

Martinsried/Paris - Sanofi has done some Christmas shopping in Munich and has licensed Scil Technology’s programme for the regenerative treatment of osteoarthritis and cartilage disorders. Under the agreement, Scil could reap up...

GermanyGermany

20.12.2011

Monheim - It's nearly Christmas, and Bayer Crop Science gives out some presents. As the company announced, a $750 million settlement with U.S. rice farmers is now binding and can move forward. In summer the German firm had agreed...

GermanyGermany

16.12.2011

Bonn – Germany’s federal government is prolonging one of its most successful measures to date for stimulating the establishment of high-tech companies – the High-Tech-Gründerfonds (HTGF). The HTGF was launched in 2005 with €272m...

GermanyGermany

15.12.2011

Leverkusen – One short statement from the European Medicines Agency (EMA) means one giant step for German biotech company Biofrontera. The agency issued a favourable opinion on the firm’s marketing approval application for its...

GermanyGermany

15.12.2011

While the European sovereign debt crisis keeps capital markets in a choke-hold, with potential negative effects on the financing situation in many industries – including biotech – there was encouraging news for drug-developing...

GermanyGermany

08.12.2011

Heidelberg – There is still life in the European life science finance. EMBL Ventures has closed a €40m fund. The early stage investor and the venture capital arm of the European Molecular Biology Laboratory(EMBL) announced the...

GermanyGermany

03.11.2011

Düsseldorf – BIO-Europe 2011 in Düsseldorf has again broken all previous records in terms of participants and company numbers. More than 3,000 representatives from 1,800 companies registered for Europe‘s largest partnering event....

GermanyGermany

02.11.2011

Brussels/San Francisco – As the biggest biotech partnering event on the continent, BioEurope, draws to a close, the venture capital community sent ambivalent messages for life sciences. Dow Jones VentureSource, an analyst,...

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