GermanyGermany

New findings pave the way for causative treatment of osteoporosis

18.05.2009

Berlin – German researchers have identified a novel molecular target that paves the way for causative therapy of osteoporosis, the most common bone disease of post-meno¬pausal women. It is estimated that 1 in 3 women and 1 in 12 men over the age of 50 worldwide have osteoporosis, which causes high healthcare costs because the reduction in bone mineral density in course of the disease leads to an increased risk of fracture. Together with colleagues from the Netherlands and the US, researchers under Professor Achim Leutz from Berlin-based Max-Delbruck Center for Molecular Medicine discovered now that the observed disequilibrium between bone-forming cells (osteoblasts) and bone-resorbing osteoclasts is caused by an imbalance of two differently translated forms of the CCAAT/enhancer-binding protein beta (C/EBPbeta), which regulate transcription of the mafB gene. The long form of C/EBP-beta (“LAP”) led to mafB-directed inhibition of osteoclast formation, the short one (LIP) activated the production of the bone resorbing cells. Rapamycin, an inhibitor of mTOR increased the ratio of LAP over LIP and inhibited osteoclastogenesis. The researchers said they now want to find alternative regulators of C/EBPbeta translation that don’t show the immunosuppressive effects of Rapamycin.

GermanyGermany

07.03.2012

The first of February marked a milestone for Leverkusen-based Bio­frontera AG in more ways than one. It was the first day that Ameluz, the firm’s first approved product, could be sold in German pharmacies. It was also the date...

GermanyGermany

07.03.2012

Darmstadt – German pharmaceutical and chemical company Merck KGaA has set a downbeat tone for 2012. CEO Karl-Ludwig Kley said the recently launched cost-cutting programme and tough economic conditions will weigh on profits this...

GermanyGermany

05.03.2012

Mainz/Leuna – Two biotech concepts were amongst the winners of the recent third round of the Excellence Cluster initiative, which is funded by the German Ministry for Research. In Mainz the champagne corks popped especially loud...

GermanyGermany

05.03.2012

German Merck KGaA has closed a licencing agreement with US-based Threshold Pharmaceuticals Inc. The cooperation centres around the hypoxia­-activated drug TH-302, which is currently being studied in a global Phase III study....

GermanyGermany

29.02.2012

Munich – Looking back with satisfaction and bent on a prize for good behaviour, German biopharmaceutical company Wilex AG reported yesterday on the fiscal year 2011 and outlined the shores in sight. The 2011 total revenue was...

GermanyGermany

17.02.2012

Brussels – European cartilage researchers intensify their cooperation. The 'gristle network' comprises scientists from Belgium, France, Germany and Luxembourg. Its members plan to meet regularly to exchange views and information...

27.01.2012

Thousand Oaks/Munich - Bling bling for blinatumomab. It is a compliment for the European life sciences scene and sad news at the same time. Amgen Inc., the world's largest biotechnology company, agreed to buy Micromet Inc., an...

GermanyGermany

20.01.2012

Martinsried - SHELTER is responsible for the fact that the stocks of 4SC behaved like a rodeo horse on Thursday. The shares rose in several stages up to 63%, only to settle at a mere 43% rise at the end of the day. SHELTER is a...

GermanyGermany

17.01.2012

Ludwigshafen – BASF Plant Science GmbH, the agrochemistry and biotech arm of the world-largest chemistry company, thinks that it has outstayed its welcome in Europe. Over the next two years, most of the green biotechnology...

GermanyGermany

10.01.2012

Munich - It is the accolade for Micromet. The German company, which is listed on the U.S. stock exchange, announced today that it has entered into a Cooperative Research and Development Agreement (CRADA) with the renowned US...

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