Denmark, Germany, France, UKFrance

Mosquito genes unlock malaria secrets

02.10.2009

Strasbourg – By studying mosquito genomes, researchers have identified differences in the expression of a single gene that determines whether or not a mosquito can transmit malaria parasites. This discovery provides a genetic basis for the variability seen in the vector capacity of different mosquito populations - some are able to kill the malaria parasites themselves, while others become unwitting transmitters. Stephanie Blandin from INSERM in Strasbourg and co-workers from Munich, Liverpool and Copenhagen combined RNA interference studies with genome-wide mapping to show that a single gene in mosquitoes infected with malaria parasites express the TEP1 protein differently within populations, and that those differences determine whether or not the malaria parasites will be killed by the mosquito’s own immune responses or be transmitted to a new host. The researchers observed various expression levels of the TEP1 gene in mosquitoes and noted how they affected the rodent malaria parasite Plasmodium berghei. Their results indicate that TEP1 expression – and the action of any additional genes that influence the TEP1 protein – determines the fate of the rodent malaria parasites in mosquitoes. These findings could offer new tools for controlling malaria transmission in the future.

FranceFrance

19.08.2011

Marcy l’Etoile – French in vitro diagnostics group Biomérieux S.A. informed the markets that it has acquired Argene, a French company specialising in molecular diagnostics for immuno­compromised patients. Biomérieux said it was...

FranceFrance

17.08.2011

Paris – A team consisting of French scientists and biotech start-up Epixis SA has developed a novel hepatitis C vaccine based on retrovirus-derived virus-like particles (VLPs) pseudotyped with the heterologous viral envelope...

FranceFrance

10.08.2011

Neuilly/New York - Les Laboratoires Servier and Intercept Pharmaceuticals join forces for the development of diabetes drugs. France’s largest independent pharmaceutical company and the US biotech entered into a worldwide ex-U.S....

FranceFrance

20.07.2011

Paris/New Haven - Sanofi pays a $9m milestone payment to Rib-X Pharmaceuticals, Inc. The French pharmaceutical company recently signed worldwide research collaboration and option for license for novel classes of antibiotics...

FranceFrance

12.07.2011

French drug maker Sanofi SA announced mixed results of a late-stage trial of multiple sclerosis drug Lemtrada. The two-year study CARE-MS I is the first of two randomised, Phase 3 clinical trials comparing Sanofi's alemtuzumab to...

FranceFrance

05.07.2011

French Biotech BioAlliance Pharma S.A. has announced plans to raise up toEUR 16.6 million through the sale 3.4 million shares at EUR 4.90 in a rightsissue. The price is a 20% discount to BioAlliance's closing price of EUR6.10...

FranceFrance

14.06.2011

Paris – Pulmonary arterial hypertension (PAH), a severe disease of the arterial blood vessels in the lungs, leads to chronically elevated pulmonary artery pressure and remodelling of the small pulmonary arteries (SMPs) as a...

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