Finnish researchers lay groundwork for targeted therapy of fibroids


Helsinki – Finnish researchers are likely to have identified the mutation that drives tumorigenesis in millions of women suffering from uterine leiomyomas (fibroids). The benign tumours, which are the most common medical reason for hysterectomy, cause abdominal pain and discomfort or abnormal bleeding in 25-50% of affected women. In Science, the researchers under Dr. Lauri Aaltonen from the University of Helsinki report, they identified a mutation in exon 2 of the mediator complex subunit 12 (Med12), a transcriptional regulator that bridges DNA regulatory sequences to the RNA polymerase II complex, in 70% of more than 200 fibroids analysed by exome sequencing. Until now, the cause of fibroids was unclear with around 145 mutations linked to the disorder. But now it seems, the researchers have identified a major driver of disease.
"The findings are a giant step towards understanding why fibroids arise,“ said professor Aaltonen, „but towards design of targeted therapies it is a very early step. Let's hope that this journey has begun."



Helsinki – According to a new survey, Finnish high-tech growth companies raised almost a51m in the first half of 2009, 17% down on the first half of 2008. Second quarter funding decreased by more than 50% from the same period in...



Helsinki – The Finnish government has announced plans to introduce tax incentives for companies with high research and development activities. At the end of June, a working group from the Ministry of Employment and Economy (MEE)...



Espoo – Finnish pharmaceutical and dia­gnostics company OrionA/S has agreed to pay Abbott US$18m to re-acquire the rights to the intravenous formulation of its heart failure treatment levosimendan, which is marketed as...



Helsinki – The Finnish Funding Agency for Technology and Innovation (Tekes), and the forest-based industry organised in the Finnish Forest Cluster have announced the five-year-research programme “Future Refinery” (FuBio), a...



Helsinki – The Finnish Government has set up a new innovation policy. As its starting point, the Science and Technology Policy Council adopted the report “Review2008” in December, which outlines Finland’s new national strategy...



A Helsinki – The causes of human anxiety disorders are largely unexplored, so there are currently no targeted drugs available for treatment. That’s why Finnish researchers from the Academy of Finland Research Programme on...



Helsinki – A proposal for national innovation strategy has laid down new outlines for reforming Finland’s innovation policy, and has presented an action programme for their implementation. The proposal was submitted on June 12th...



Helsinki – The Technology Academy Finland, an independent foundation established by Finnish industry, has announced the 4 finalists for the 2008 Millenium Technology Prize, which is awarded for technological innovation that...



Helsinki – A study conducted by the research arm of the global assurance firm Allianz SE for the Lisbon Council, a Brussels-based think tank, has concluded that Finland already fulfills all of the criteria for the so-called...



Helsinki – An international research team under Prof. Rasmus Nielsen from Copenhagen University has discovered that Europeans carry significantly more deleterious mutations in their genomes than Africans. The results are based on...

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