Finnish researchers lay groundwork for targeted therapy of fibroids

26.08.2011

Helsinki – Finnish researchers are likely to have identified the mutation that drives tumorigenesis in millions of women suffering from uterine leiomyomas (fibroids). The benign tumours, which are the most common medical reason for hysterectomy, cause abdominal pain and discomfort or abnormal bleeding in 25-50% of affected women. In Science, the researchers under Dr. Lauri Aaltonen from the University of Helsinki report, they identified a mutation in exon 2 of the mediator complex subunit 12 (Med12), a transcriptional regulator that bridges DNA regulatory sequences to the RNA polymerase II complex, in 70% of more than 200 fibroids analysed by exome sequencing. Until now, the cause of fibroids was unclear with around 145 mutations linked to the disorder. But now it seems, the researchers have identified a major driver of disease.
"The findings are a giant step towards understanding why fibroids arise,“ said professor Aaltonen, „but towards design of targeted therapies it is a very early step. Let's hope that this journey has begun."

FinlandFinland

03.11.2010

Turku/Freiburg – EU researchers led by scientists at the University of Turku have begun designing a bacterium able to produce liquefied petroleum gas (LPG) from sunlight. “We have all the parts to put the ability for production...

FinlandFinland

19.09.2010

Rajamäki/Darmstadt – A cooperation project between AB Enzymes Oy and Royal Oy has resulted in the discovery of an enzyme that enables washing temperature to be dropped to as low as 10° C. The project is being funded by the SymBio...

FinlandFinland

08.07.2010

Turku – Finland’s Faron Pharmaceuticals Ltd. has announced a cooperation with German biotech company Priaxon AG to create new scaffold structures to modify the AOC3-protein function and its ligand interaction with orally...

FinlandFinland

09.06.2010

Tampere – Short people are at greater risk of developing heart disease than tall people, according to a meta-analysis of 52 populations-based studies including 3 million people by Finnish researchers (Eur. Heart J.,...

FinlandFinland

12.05.2010

Reykjavik – Researchers from the Icelandic bio­tech company deCODE – together with colleagues from 23 institutions in a dozen countries – have determined that genetic factors influence both nico­tine dependence and the incidence...

FinlandFinland

11.05.2010

Turku – Finnish Biotie Therapies Corp. confirmed that its oral phospho­diesterase 4 inhibitor ELB353 has proven safe and pharmacologically active in a Phase I study. Pharmacokinetic data point to the suitability of ELB353 for a...

FinlandFinland

07.03.2010

Helsinki/Hinxton – Finland has pledged EUR1.85m to help create world-class bio­informatics, biobanking and translational research infrastructures, the European Bioinformatics Institute (EBI) at the European Molecular Laboratory...

FinlandFinland

04.02.2010

Helsinki –Finland is investing EUR1.9m in creating world class bioinformatics, biobanking and translational research infrastructures. The investment comes as part of the linkage of three large EU projects ELIXIR, BBMRI, and...

FinlandFinland

01.02.2010

Helsinki – The Academy of Finland is restructuring its funding instruments. The purpose of the reform, which will be finalised in fall 2010, is to give greater clarity and flexibility to Finnish researchers, and to improve the...

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