Finnish researchers lay groundwork for targeted therapy of fibroids

26.08.2011

Helsinki – Finnish researchers are likely to have identified the mutation that drives tumorigenesis in millions of women suffering from uterine leiomyomas (fibroids). The benign tumours, which are the most common medical reason for hysterectomy, cause abdominal pain and discomfort or abnormal bleeding in 25-50% of affected women. In Science, the researchers under Dr. Lauri Aaltonen from the University of Helsinki report, they identified a mutation in exon 2 of the mediator complex subunit 12 (Med12), a transcriptional regulator that bridges DNA regulatory sequences to the RNA polymerase II complex, in 70% of more than 200 fibroids analysed by exome sequencing. Until now, the cause of fibroids was unclear with around 145 mutations linked to the disorder. But now it seems, the researchers have identified a major driver of disease.
"The findings are a giant step towards understanding why fibroids arise,“ said professor Aaltonen, „but towards design of targeted therapies it is a very early step. Let's hope that this journey has begun."

FinlandFinland

08.03.2012

The vaccine research centre of the University of Tampere in Finland has out­licenced a candidate combined prophylactic vaccine against norovirus and rota­virus infections. The Japanese vaccine venture UMN Pharma Inc. acquired the...

FinlandFinland

07.03.2012

Finnish protein manufacturer Vectron Biosolutions AS has completed a study comparing different expression technologies. According to Vectron, their proprietary E. coli expression technology gave higher yields for seven out of ten...

FinlandFinland

02.03.2012

Lappeenranta – Finnish paper industry major UPM plans to invest in an industry-scale biorefinery producing biofuels from crude tall oil, a by-product of the wood pulp manufacturing process. UPM’s total investment will amount to...

FinlandFinland

18.12.2011

Helsinki/Göttingen – Finnish laboratory supplier Biohit Oyj has sold its liquid handling business for €68m to German process and labtech provider Sartorius AG. Osmo Suovaniemi, founder and Chairman of the Board at Biohit,...

FinlandFinland

17.12.2011

Porvoo/Chalfont St. Giles – GE Healthcare and Neste Jacobs have formed a strategic alliance to drive worldwide self-sufficiency in blood plasma fractionation. Finnish-based Neste Jacobs Oy, a global expert in plant engineering...

FinlandFinland

31.10.2011

Bresso/Turku – The wedding's off between Newron and Biotie. The bride has run away. Shares in Italy's Newron Pharmaceuticals plunged after its proposed merger with Biotie Therapies Corp was called off by the Finnish firm....

FinlandFinland

28.09.2011

Turku/ Bresso – It is both good and bad news for the Italian biotechnology sector: Finnish Biotie Therapies ASA has signed an agreement to acquire Newron Pharmaceuticals S.p.A. for €45 million. On the down side, Italy loses one...

FinlandFinland

04.04.2011

Hafnarfjodur – Actavis Group CEO Claudio Albrecht announced at the beginning of February that the company may go public within the next 2-3 years, although it isn’t clear whether the generics manufacturer would conduct an IPO,...

FinlandFinland

11.02.2011

Helsinki – Using laser light to destroy tumour cells lodged in lymphatic vessels can halt the spread of cancer, Finnish researchers headed by Tuomas Tammela have demonstrated. Their approach to destroy the tumour cells, which use...

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