DenmarkDenmark

No relief for alcoholics yet after Lundbeck Phase III results

06.03.2012

Prague/Turku/Copenhagen – Danish pharmaceutical company H. Lundbeck A/S yesterday unveiled clinical data on its potential blockbuster drug nalmefene at the 2012 European Congress of Psychiatry clinical in Prague. While Lundbeck and its Finnish partner Biotie Therapeutics Corp. from Turku underline an impressive 66% reduction in total alcohol consumption, a closer look at placebo data is disconcerting. In three placebo-controlled Phase III studies, the drug with the trade name Selincro was given to heavy drinkers who also were given medical advice about their drinking habits. Selincro aims at eliminating the brain's pleasure response to drinking. After six months, numbers of heavy drinking days (total alcohol consumption) in the first study dropped from 19 to 7 (84g to 30g) in the drug arm, and from 20 to 10 (85g to 43g) in the placebo arm. The numbers of the second study were less convincing and – even worse – in the third study the drug arm barely outperformed the placebo. Nevertheless Biotie-CEO Timo Veromaa thinks that "Selincro has the potential to transform the way alcohol dependence is managed by both patients and physicians." Right now, the flipped coin is in the air, not landing heads or tails until the review of the European application is out. But even if admission was granted, Selincro's success would remain at stake: According to analysts at Jefferies, the drug could reap up to $300 million in annual sales in Europe – not exactly a harvest of blockbuster dimensions. Also squinting at the US won't bring any sparkle to investors' eyes as there, the permitted market window for the drug would only be open for 5 years. Therefore, all eyes will be focussed on the follow-up Phase III data presented in June at the Annual Research Society on Alcoholism Scientific Meeting in San Francisco. In the meantime the coin's trajectory will be watched, closely.

DenmarkDenmark

15.08.2011

Copenhagen – Driven by strong sales, Danish drugmaker Lundbeck A/S reported hefty QII/2011 profits, and says it is now expecting full-year results at the upper end of its guided range. Operating profit rose to DKK1.1bn in the...

DenmarkDenmark

12.08.2011

Copenhagen - All is well in Denmark - for now. Danish Drugmaker Lundbeck reported excellent profits in the second quarter but announced its intention to prepare for deep cuts in research. 175 jobs in Denmark and the US (12.5% of...

DenmarkDenmark

06.06.2011

Kvistgaard – Bavarian Nordic A/S of Denmark has raised DKK698m (EUR94m)through a rights issue to fund development of its prostate cancer vaccine Prostvac. A total of 12.9 million shares were sold at DKK54. The company announced...

DenmarkDenmark

12.04.2011

Kvistgaard – Net loss at Danish biopharmaceutical company Bavarian Nordic A/S increased to DKK390m from DKK266m in the previous year, even though revenue grew to DKK314m, up from DKK75m in 2009. Bavarian Nordic’s lead product is...

DenmarkDenmark

09.04.2011

Copenhagen – Despite recent setbacks, Danish TopoTarget A/S still has hopes for its histone deacetylase (HDAc) blocker belinostat (PXD01). The cytotoxic compound for treating lymphoma and solid tumours has failed to show...

DenmarkDenmark

16.11.2010

Vedback – Danish biotech company Exiqon A/S has reported data showing a significant shortening of progression-free survival in 130 stage II colon patients expressing high levels of microRNA21 (miR-21) in stromal cells surrounding...

Displaying results 11 to 20 out of 194

< Previous 11-20 Next >

© 2007-2014 BIOCOM

http://www.european-biotechnology-news.com/nc/news/messages-archive/archive-denmark/browse/1/article/no-relief-for-alcoholics-yet-after-lundbeck-phase-iii-results.html

Product of the week

Products

Events

All Events

Current issue

All issues