Czech/SlovakiaCzech RepublicSlovakia

Deadly delivery

09.08.2011

Praque – A team of researchers headed by Dr. Valdimir Kral, Director of Chemical Development at Sanofi-Aventis’ Czech research unit Zentiva Development sro, has presented a new targeted drug delivery system that couples combined delivery of cytostatics and therapeutic antibodies to tumours with photodynamic therapy (Bioorg Med Chem Letter, doi:10.1016/j.bmcl.2011.06.101). Their new nanocarrier consists of a cyclodextrin shell enclosing the chemotherapeutic that is attached to a zinc-porphyrin system. This accumulates in tumour cells, and can bind immuno­globulins via the 5th coordination site of the Zn complex. According to the researchers, the system can be just as readily used for a variety of therapeutic and targeting proteins, including antibodies, lectins, and HSA. The new carrier allows an attack on tumours from three fronts. Porphyrine accumulates in them, leading to photo-­oxidative tumour damage upon light activation (photodynamic therapy). Additionally, the system guides cell-toxic chemotherapeutics and cancer-selective immuno­therapeutics into tumour cells. And when tested in a mouse model with human C32 carcinoma, the coordination assembly nanosystem was shown to be therapeutically superior in terms of efficacy to the building blocks used for the construction of the system alone.

Czech/SlovakiaCzech RepublicSlovakia

07.03.2012

The Czech government has beefed up its investments in biotech with the help of EU structural funds. In February, the country’s Education Minister Josef Dobes gave the go-ahead for the Biocev centre in Vestec near Prague. Although...

Czech/SlovakiaCzech RepublicSlovakia

05.12.2011

Brno – Czech Prime Minister Petr Necas has officially inaugurated the first of six European Technology Institutes slated to be launched in the Czech Republic with help from European FEDER funds. Although construction of the €200m...

Czech/SlovakiaCzech RepublicSlovakia

01.10.2011

Prague – Czech drug developer VUAB Pharma a.s. has joined CzechBio. The company, which has its headquarters in Roztoky near Prague, became the 35th member of the Czech biotechnology industry association in September. VUAB...

Czech/SlovakiaCzech RepublicSlovakia

01.06.2011

Brno – Plans for building a Central European Insitute of Technology (CEITEC) in Brno look set to take a big step closer to becoming reality. In mid-May, CEITEC representatives announced that EU financing for the EUR260m...

Czech/SlovakiaCzech RepublicSlovakia

03.11.2010

Plzen – Czech antibody discovery and development specialist AbCheck s.r.o. has signed its first contract with a big pharma company. In October, the yearling Czech spin-off from German antibody drug developer Affimed GmbH...

Czech/SlovakiaCzech RepublicSlovakia

13.09.2010

Prague – CzechInvest has called on Czech high-tech companies in the field of ICT, bio­technology, clean technology and micro­electronics to apply for the Czech Technology Accelerator programme. Under the third call, which was...

Czech/SlovakiaCzech RepublicSlovakia

02.07.2010

Prague – Czech researchers from Charles University in Prague have discovered a molecular biomarker that helps to predict toxicity and a higher risk for adverse effects in children with juvenile arthritis that are treated with...

Czech/SlovakiaCzech RepublicSlovakia

12.05.2010

Prague – Czech biotech company Lenti­Kats AS has begun worldwide commercialisation of a patented, cost-effective encapsulation technology for use in the food and bio­pharmaceuticals industry. The company has discovered a way to...

Czech/SlovakiaCzech RepublicSlovakia

12.05.2010

Sofia – Bulgaria’s parliament has approved a law that will in effect ban any cultivation of GMO crops in the country. “There will be no field on the country’s territory where GMOs can be cultivated,” said Kostadin Yazov from the...

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