BeNeLuxBelgiumNetherlandsLuxembourg

Abbott bags Galapagos' first-in-class compound against rheumatoid arthritis

01.03.2012

Illinois/Mechelen – US pharma major Abbott has paid US$150m upfront to Belgian biotech firm Galapagos NV to enter into a global development and distribution partnership for its first-in-class selective oral JAK1 blocker that has recently proved effective in patients with rheumatoid arthritis (RA). Under the terms of the agreement, Abbott has secured an option to license the programme for a one-time fee of U$200m. In that case, Abbott will assume sole responsibility for Phase III clinical development and global manufacturing. Pending the achievement of certain developmental, regulatory, commercial and sales-based milestones, Galapagos would be eligible to receive additional milestone payments from Abbott, potentially amounting to US$1bn, in addition to tiered double-digit royalties on net sales upon commercialisation. Galapagos retains co-promotion rights in Belgium, the Netherlands and Luxembourg.
With the deal, Abbott enters a competition with Pfizer and Vertex, who also have JAK kinase blockers against RA under development. According to the results from an exploratory Phase II trial published last November, 83% of the 36 patients receiving GLPG0634 reached the ACR20 score and half of the treated patients went into either disease remission or low disease activity. Furthermore the compound showed no anaemia, change in blood pressure of lipids. Onno van de Stolpe, CEO of Mechelen, Belgium-based Galapagos, was also keen to emphasise the trial had demonstrated a better safety profile than other JAK inhibitors, which are in development for rheumatoid arthritis. They include two potential blockbuster DMARDS: Pfizer's tofacitinib and Vertex Inc.'s VX509, which is in Phase II.

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01.09.2011

New York - US-American investment firm OrbiMed announced the closing of a new fund for life science companies in the health sector. The fund acquires healthcare royalty streams and provides structured debt capital to healthcare...

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Liège – A Belgian research team from the University of Liège’s GIGA-Research centre has discovered an unexpected mode of action for the vaccine adjuvant alum. The team discovered that when a vaccine containing alum is injected...

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Amsterdam – Dutch molecular diagnostics specialist Agendia B.V. postponed its initial public offering in June because of volatile market conditions, revealing that the financing environment for bio­tech firms remains tough....

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Dutch gene therapy specialist Amsterdam Molecular Therapeutics BV (AMT) has filed a re-examination request for its lead product Glybera. At the end of June, EMA's CHMP recommended against approval of the product to treat...

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Ghent – The Flanders Institute for Biotechnology VIB will receive EUR3m from the European Commission for the recruitment and training of promising international scientists in the life sciences. This will allow VIB to further...

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Brussels – Belgian specialist for regenerative medicine TiGenix NV has raised EUR15.2m through the sale of 15.2 million shares at EUR1/share in a rights issue. Existing shareholders, who were eligible to purchase one share for...

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