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Abbott bags Galapagos' first-in-class compound against rheumatoid arthritis

01.03.2012

Illinois/Mechelen – US pharma major Abbott has paid US$150m upfront to Belgian biotech firm Galapagos NV to enter into a global development and distribution partnership for its first-in-class selective oral JAK1 blocker that has recently proved effective in patients with rheumatoid arthritis (RA). Under the terms of the agreement, Abbott has secured an option to license the programme for a one-time fee of U$200m. In that case, Abbott will assume sole responsibility for Phase III clinical development and global manufacturing. Pending the achievement of certain developmental, regulatory, commercial and sales-based milestones, Galapagos would be eligible to receive additional milestone payments from Abbott, potentially amounting to US$1bn, in addition to tiered double-digit royalties on net sales upon commercialisation. Galapagos retains co-promotion rights in Belgium, the Netherlands and Luxembourg.
With the deal, Abbott enters a competition with Pfizer and Vertex, who also have JAK kinase blockers against RA under development. According to the results from an exploratory Phase II trial published last November, 83% of the 36 patients receiving GLPG0634 reached the ACR20 score and half of the treated patients went into either disease remission or low disease activity. Furthermore the compound showed no anaemia, change in blood pressure of lipids. Onno van de Stolpe, CEO of Mechelen, Belgium-based Galapagos, was also keen to emphasise the trial had demonstrated a better safety profile than other JAK inhibitors, which are in development for rheumatoid arthritis. They include two potential blockbuster DMARDS: Pfizer's tofacitinib and Vertex Inc.'s VX509, which is in Phase II.

BeNeLuxBelgiumNetherlandsLuxembourg

05.10.2011

Luxembourg - For its tiny size, Luxembourg attracts a disproportionally huge amount of venture capital. Creabilis SA has raised €15m in a Series B funding round led by Abbott Biotech Ventures. "In Abbott, we have added another...

BeNeLuxBelgiumNetherlandsLuxembourg

01.10.2011

Munich/Amsterdam – Researchers from the LMU Munich and the Aca­demic Medical Center Amsterdam have found a way to predict disease outcome in patients with life-threatening bacterial meningitis. In a nation­wide genetic...

BeNeLuxBelgiumNetherlandsLuxembourg

01.10.2011

Utrecht – Consuming fish or fish oil capsules may be a bad idea for cancer patients, according to Dutch researchers. In mid-September, a team headed by Emile Voest from the University Medical Centre Utrecht reported such products...

BeNeLuxBelgiumNetherlandsLuxembourg

01.10.2011

Rotterdam – Finnish oil refining company Neste Oil corporation has kick-started production in Europe’s largest renewable diesel refinery in Rotterdam. The plant has a capacity of 800,000 tonnes a year, and this will be ramped up...

BeNeLuxBelgiumNetherlandsLuxembourg

01.10.2011

Brussels – A European gateway to life science capacities has been launched (www.toolsofscience.eu) that is aimed at providing a novel resource for identifying the best facilities and service companies from among 13 bioregions...

BeNeLuxBelgiumNetherlandsLuxembourg

01.10.2011

Stockholm/Leiden/Barcelona – A complicated ménage a trois has come to an end: Swedish Orphan Biovitrum AB, Pharming Group N.V. and Esteve S.A. announced at the beginning of September that they were terminating a 2004 deal...

BeNeLuxBelgiumNetherlandsLuxembourg

14.09.2011

Bunnik – AM-Pharma B.V. has raised €29.2m. The Dutch company plans to spend the money on delivering a human recombinant form of Alkaline Phosphatase (AP) as a treatment for Acute Kidney Injury (AKI) from preclinical stages to the...

BeNeLuxBelgiumNetherlandsLuxembourg

13.09.2011

Utrecht – Researchers at University Medical Center Utrecht have dealt a blow to the advocates of allegedly healthy fish oil. The substance which is again and again named as a helpful substance for cancer patients, seems instead...

BeNeLuxBelgiumNetherlandsLuxembourg

07.09.2011

Diepenbeek - Amakem has received €18m to take a glaucoma drug candidate through Phase II trials. The Belgium-based developer lead candidate will use the money to advance its lead candidate AMA0076 to the clinical proof of...

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