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Fish oil reduces effectiveness of chemotherapy

13.09.2011

Utrecht – Researchers at University Medical Center Utrecht have dealt a blow to the advocates of allegedly healthy fish oil. The substance which is again and again named as a helpful substance for cancer patients, seems instead to have an uniquely adverse effect on nearly all types of chemotherapy – making cancer cells insensitive to the treatment, the researchers report in Cancer Cell (Online publication, 13th September). The basis of the research was the observation, that chemotherapy seems to get less effective over time. It appears that chemotherapy is made ineffective by two types of fatty acid that are made by mesenchymal stem cells in the blood. Under the influence of cisplatin chemotherapy, stem cells secrete fatty acids which induce resistance to a broad spectrum of chemotherapies. The problem is: The fatty acids are also found in commercially-produced fish oil supplements containing omega-3 and omega-6 fatty acids as well as in some algae extracts. The researchers refer to the acids 'PIFAs' which stands for platinum-induced fatty acids. The researchers studied the effect of PIFA's in mice and human cells. The mice studied had tumours under the skin. In the experiments, the tumours became insensitive to chemotherapy after administration of normal amounts of fish oil. "We currently recommend that these products should not be used whilst people are undergoing chemotherapy", says Emile Voest, a medical oncologist at UMC Utrecht, who supervised the research.

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16.12.2011

Mechelen - Galapagos NV confirms its status as one of Europe best drug discovery companies. The Belgian biotech received €4 million as the first milestone payments from French Servier for the discovery of new targets for...

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15.12.2011

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28.11.2011

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23.11.2011

Mechelen – Belgian drugmaker Galapagos NV has reported impressive results of a proof-of-concept trial with its oral janus kinase 1 blocker GLPG0634 + Methothrexate in patients with active rheumatoid arthritis. In the 24 patients...

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18.11.2011

Naarden – Enzyme replacement therapies specialist Oxyrane NV raised €20 million in a series D round of financing. The therapies are designed to treat lysosomal storage diseases, a class of more than forty rare inherited diseases....

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14.11.2011

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09.11.2011

New York/Ghent - Big brother is gone. Belgian biotech Ablynx regained the rights for nanobodies targeting TNF-alpha from Pfizer. The US- pharma outfit decided it did't want ATN-103, even though it met its goal in a mid-stage...

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25.10.2011

Amsterdam - The second blow could be the ultimate one. Amsterdam Molecular Therapeutics received a second negative opinion for Glybera to treat lipoprotein lipase (LPL) deficiency. The European Medicines Agency's (EMA) Committee...

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Bilthoven – The current impact of hospital acquired infections with multi-resistant bugs is lower than suggested by startling news articles. According to a study of Dutch researchers, bloodstream infections caused by...

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