AustriaAustria

New collaborator in vaccine game

03.11.2010

Vienna – Austrian vaccine specialist Intercell AG has landed a new partner for its therapeutic vaccine IC41 against chronic infections with the hepatitis C virus (HCV) after Novartis quit a a 270m partnership with the firm this summer. In Octo­ber, the company announced it will begin working with Florida-based Romark Laboratories L.C. in clinical development. Clinical Phase II trials that are expected to be initiated in the first half of 2011 will focus on testing a combination of Intercell’s therapeutic peptide vaccine with Romark’s antiviral thiazol compound nitazoxanide in 60 treatment-naive patients. The endpoint of the study – “no detectable HCV RNA 24 weeks after end-of-treatment”– will be determined in three study arms: IC41+nitazoxanide, IC41+nitazoxanide+ peg-interferon a2a (Pegasys®) and the current treatment standard Pegasys®+ ribavirin.
In a previous proof-of-concept Phase II trial with 50 previously untreated patients, Intercell says IC41 had achieved “viral load reductions of more than 75 % in patients with high baseline RNA levels for at least 6 months.” IC41 consists of five synthetic peptides (IPEP83, 84, 87, 89, 1426) harbouring CD4 and CD8 T-cell epitopes of HCV and the synthetic adjuvant poly-L-arginine.

AustriaAustria

17.03.2011

Vienna – Apeiron Biologics has entered into an exclusive option with the Cleveland Clinic to license a number of novel compounds that are currently in development there. The drug candidates are designed to fight cancer by...

AustriaAustria

06.02.2011

Vienna – Austrian vaccine specialist Intercell has halted the development of its travellers’ diarrhea vaccine patch after the product failed in a Phase III trial. The company’s management says it will now align its structure to...

Clinical Trial, AustriaAustria

06.02.2011

Vienna – Austrian Nabriva Therapeutics AG has recruited 210 patients for a Phase II study with its antibiotic BC-3781, a substance for treating acute bacterial skin infections. In the study, Nabriva will compare response rates of...

AustriaAustria

02.02.2011

Vienna/Darmstadt – Austrian Apeiron Biologics AG has in-licensed Merck's KgaA’s antibody-interleukin fusion protein hu14.18-IL2 for an undisclosed sum. The drug candidate, that is ready to be tested in Phase III studies, binds to...

AustriaAustria

16.12.2010

Vienna – Austrian Affiris AG has bagged EUR368.000 from the Michael J. Fox Foundation within the Parkinson’s Progression Markers Initiative for completion of preclinical development of its PD01 vaccine against Parkinson’s...

AustriaAustria

04.11.2010

Innsbruck – Cholesterol-lowering drugs widely used to prevent heart disease can also boost anti-cancer effect of interleukine-2 (IL-2) immune therapy. When added to tumour cell cultures treated with IL-2, statins dose-dependently...

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