AustriaAustria

Nabriva clears first big hurdle in proof-of-concept study

11.06.2011

Vienna – Nabriva Therapeutics AG, an Austrian specialist for the development of novel antibiotics, has achieved proof-of-concept for its first product in a clinical Phase II study. Called BC-3781, the compound is used to treat acute bacterial skin and skin structure infections. It is the first substance in a new class of system­ically available pleuromutilin anti­biotics for the treatment of serious skin infections and pneumonia. BC-3781 is being developed for both oral and intravenous formulations. In 207 patients recruited in 23 centers in the US, the study compared two doses of BC-3781 with Vancomycin, the gold standard for drug resistant Gram-positive bacterial skin infections. Nabriva was able to show non-inferiority compared to Vancomycin. Patients receiving BC-3781 in two different dose regimens (100mg and 150mg) showed a similar treatment success compared to Vancomycin. Nabriva is the successor of the Antibiotics Research Institute (ABRI), a former affiliate of Sandoz AG. The decision to spin-out antibiotics research in 2006 followed a strategic re-orientation of the Sandoz unit within the mother company Novartis. Nabriva’s shareholders include a big-name investor syndicate made up of Phase4 Ventures, HBM, The Wellcome Trust, GLSV and the Novartis Venture Fund.

AustriaAustria

06.02.2011

Vienna – Austrian vaccine specialist Intercell has halted the development of its travellers’ diarrhea vaccine patch after the product failed in a Phase III trial. The company’s management says it will now align its structure to...

Clinical Trial, AustriaAustria

06.02.2011

Vienna – Austrian Nabriva Therapeutics AG has recruited 210 patients for a Phase II study with its antibiotic BC-3781, a substance for treating acute bacterial skin infections. In the study, Nabriva will compare response rates of...

AustriaAustria

02.02.2011

Vienna/Darmstadt – Austrian Apeiron Biologics AG has in-licensed Merck's KgaA’s antibody-interleukin fusion protein hu14.18-IL2 for an undisclosed sum. The drug candidate, that is ready to be tested in Phase III studies, binds to...

AustriaAustria

16.12.2010

Vienna – Austrian Affiris AG has bagged EUR368.000 from the Michael J. Fox Foundation within the Parkinson’s Progression Markers Initiative for completion of preclinical development of its PD01 vaccine against Parkinson’s...

AustriaAustria

04.11.2010

Innsbruck – Cholesterol-lowering drugs widely used to prevent heart disease can also boost anti-cancer effect of interleukine-2 (IL-2) immune therapy. When added to tumour cell cultures treated with IL-2, statins dose-dependently...

AustriaAustria

03.11.2010

Austrian vaccine developer Intercell AG (Vienna) has a new Chief Business Officer. At the beginning of October, Staph Leavenworth Bakali quit Intercell’s supervisory board and joined its management board with key responsibilities...

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