AustriaAustria

Intercell AG to cut 50% cost after termination of Phase II/III trial of Staphylococcus aureus vaccine

09.06.2011

Vienna – Austrian Intercell AG has lost its partner Merck & Co after termination of a Phase II/III trial with Intercell’s vaccine candidate V710 against Staphylococcus aureus, the most frequent cause of hospital-acquired infections. According to the independent Data Monitoring Committee analyses of the proof-of-concept study, V710 was unlikely to demonstrate statistically significant clinical benefit. Additionally, there were safety concerns due to higher overall mortality and multi-organ dysfunction events in the vaccine group, compared to placebo recipients. Shares of Intercell dropped by 25% after the announcement. At the end of May, Intercell had to recall 5,000 of its marketed vaccine Ixiaro against Japanese Encephalitis. By December, the company had terminated development of its vaccine patch in traveller’s diarrhoea due to efficacy problems. In a press conference, the company’s new CEO Thomas Lingelbach, who replaces Gerd Zettlmeisl explained that the company will refocus on its products under clinical development and will reduce its expenses by 50%, particularly in R&D. Together with jobs cuts by 15% compared to 2010 numbers, the company hopes to reduce losses in the next 4 years.

AustriaAustria

06.02.2011

Vienna – Austrian vaccine specialist Intercell has halted the development of its travellers’ diarrhea vaccine patch after the product failed in a Phase III trial. The company’s management says it will now align its structure to...

Clinical Trial, AustriaAustria

06.02.2011

Vienna – Austrian Nabriva Therapeutics AG has recruited 210 patients for a Phase II study with its antibiotic BC-3781, a substance for treating acute bacterial skin infections. In the study, Nabriva will compare response rates of...

AustriaAustria

02.02.2011

Vienna/Darmstadt – Austrian Apeiron Biologics AG has in-licensed Merck's KgaA’s antibody-interleukin fusion protein hu14.18-IL2 for an undisclosed sum. The drug candidate, that is ready to be tested in Phase III studies, binds to...

AustriaAustria

16.12.2010

Vienna – Austrian Affiris AG has bagged EUR368.000 from the Michael J. Fox Foundation within the Parkinson’s Progression Markers Initiative for completion of preclinical development of its PD01 vaccine against Parkinson’s...

AustriaAustria

04.11.2010

Innsbruck – Cholesterol-lowering drugs widely used to prevent heart disease can also boost anti-cancer effect of interleukine-2 (IL-2) immune therapy. When added to tumour cell cultures treated with IL-2, statins dose-dependently...

AustriaAustria

03.11.2010

Austrian vaccine developer Intercell AG (Vienna) has a new Chief Business Officer. At the beginning of October, Staph Leavenworth Bakali quit Intercell’s supervisory board and joined its management board with key responsibilities...

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